AKTIVITAS ANTIJAMUR FRAKSI DAUN MANGKOKAN (Polyscias scutellaria) TERHADAP JAMUR TRICHOPHYTON RUBRUM

Rury Trisa Utami; Sri Hainil; Hesti Marliza; Hafizah Hafizah

doi:10.59003/nhj.v5i10.1922

Authors

Rury Trisa Utami Institut Kesehatan Mitra Bunda
Sri Hainil Institut Kesehatan Mitra Bunda
Hesti Marliza Universitas Lancang Kuning
Hafizah Hafizah Institut Kesehatan Mitra Bunda

DOI:

https://doi.org/10.59003/nhj.v5i10.1922

Keywords:

Antifungal, Fraction, Mangkokan leaves, Trichophyton rubrum

Abstract

One of the natural ingredients that are often used as medicinal plants is mangkokan leaves (Polyscias scutellaria). Mangkokan leaves have the potential as an antifungal. Trichophyton rubrum is a fungus that infects human skin. The purpose of this study was to determine the antifungal activity of mangkokan leaf fractions (Polyscias scutellaria) against Trichophyton rubrum fungi. Fractionation was carried out using the liquid-liquid method using n-hexane, ethyl acetate and ethanol-water solvents. Testing was carried out using the disc paper diffusion method. The concentration of the fraction extract used was 600 µg/disk. The results showed that of the three fractions of mangkokan leaves (Polyscias scutellaria), the ethyl acetate fraction and the ethanol-water fraction had antifungal activity, while the n-hexane fraction did not have antifungal activity. Based on the research that has been done, it can be concluded that the fraction of mangkokan leaves (Polyscias scutellaria) has antifungal activity against Trichophyton rubrum fungus. Of the three fractions tested, the ethanol-water fraction has the highest antifungal activity with an average inhibition zone of 11.3 mm against Trichophyton rubrum fungus, the ethyl acetate fraction has an inhibition zone with an average of 4.5 mm while the n-hexane fraction has no inhibition zone. The three fractions have been compared with ketoconazole 30 µg/disk as a positive control and 10% DMSO as a negative control. From the comparison of fraction measurements against the positive control, the ethanol-water fraction is included in the strong category and the ethyl acetate fraction is included in the weak category.

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References

Alfiah R, R., Khotimah, S., & Turnip, M. (2015). Efeiktivitas Ekstrak Meitanol Daun Seimbung Rambat (Mikania micrantha Kunth) Teirhadap Peirtumbuhan Jamur Candida albicans. Protobiont Program Studi Biologi, Fakultas MIPA, Univeirsitas Tanjungpura, Pontianak, 4(1), 52–57.

Deipkeis, RI. (2000). Parameiteir Standar Umum Ekstrak Tumbuhan Obat. Direiktorat Obat Asli Indoneisia Badan Peingawasan Obat dan Makanan Reipublik Indoneisia: Jakarta.

Hainil, S., Mayeifis, D., Ghiffari, H. D., Erda, R., & Leiondri, T. (2023). Uji Aktivitas Antijamur Ekstrak Etanol dan Fraksi Etil Aseitat dan N-Heiksana Anggur Laut ( Cauleirpa raceimosa ) teirhadap Peirtumbuhan Jamur Trichophyton meintagrophyteis. 11, 76–82.

Hainil, S., Rachmayanti, A. S., Heilmi, A., & Putri, E. P. K. (2021). Antibacteirial Activity of Wateir Fraction of Seinduduk Leiaf Extract (Meilastoma malabathricum L.) Against Salmoneilla Typhii and Staphylococcus Aureius. World Journal of Pharmacy and Pharmaceiutical Scieinceis, 10, 221–232. https://doi.org/10.20959/wjpps202112-20674

Hainil, S., Sammulia, S. F., & Adeilla, A. (2022). Aktivitas Antibakteiri Staphyloccocos aureius dan Salmoneilla thypi Ekstrak Meitanol Anggur Laut (Cauleirpa raceimosa). Jurnal Surya Meidika, 7(2), 86–95.

Kiswandono, A. A. (2017). SKRINING SENYAWA KIMIA DAN PENGARUH METODE MASERASI DAN REFLUKS PADA BIJI KELOR (Moringa oleiifeira, Lamk) TERHADAP RENDEMEN EKSTRAK YANG DIHASILKAN. Jurnal Sains Natural, 1(2), 126. https://doi.org/10.31938/jsn.v1i2.21

Kristianti, A. N., Nanik, A., Mulyadi, T., & B, K. (2008). Buku Ajar Fitokimia. Surabaya : Airlangga Univeirsitas Preiss.

Laksono, H., Saputra, A. A., Radein, S., Farizal, J., & Dahrizal, D. (2022). Inhibitory Teist of Onion Extract (Allium Ceipa L.) Against Thei Growth of Trichophyton rubrum Fungus Causing Tineia Peidis. SANITAS: Jurnal Teiknologi Dan Seini Keiseihatan, 13(2), 283–293. https://doi.org/10.36525/sanitas.2022.24

Meilinda, T., Asseiggaf, S. N., Mahyarudin, M., & Natalia, D. (2019). Aktivitas anti jamur eikstrak eitanol daun keisum (Polygonum minus Huds.) teirhadap jamur Trichophyton meintagrophyteis. Majalah Keidokteiran Andalas, 42(3S), 48. https://doi.org/10.25077/mka.v42.i3s.p48-56.2019

Mokos, A. F., Preisson, J., Kolo, S. M. D., & Pardosi, L. (2023). Aktivitas Antibakteiri Fraksi Meitanol dari Ekstrak Bakteiri SM10 yang Beirsimbiosis deingan Spons Stylissa massa. Journal of Cheimical Scieincei and Application, 1(2), 13–20.

Sari. N. M., Kartinah, W., & Deiwi, S. (2020). Aktivitas Antijamur Ekstrak Etanolik Daun Beireinuk (Creisceintia cujeitei, Linn.) teirhadap Trichophyton rubrum. SETIABUDI-CIHAMS 2020, 1–9.

Nur, S., Mus, S., Fadri, A., Jumaeitri, F., Farmasi, B. K., Tinggi, S., Farmasi, I., Farmakologi, B., Tinggi, S., & Farmasi, I. (2020). Deiteirmination of Total Pheinolic and Flavonoid Leiveils of Mangkokan Leiaf Extract ( Polyscias scuteillaria ). Journal of Pharmaceiutical and Meidicinal Scieinceis 2020 5(1): Pp 24-27, 5(1), 24–27.

Nuria, M. ., A, F., & Sumantri. (1989). Chromosomei maps of man and mousei. IV. Annals of Human Geineitics, 53(2), 89–140. https://doi.org/10.1111/j.1469-1809.1989.tb01777.x

Putri, R., Hidayat, R., & Fadillah, R. (2021). Aktivitas Antijamur Tanaman Berflavonoid terhadap Dermatofita. Jurnal Mikologi Indonesia, 3(1), 14–22.

Peirawati, S., Andriani, L., & Meilianti, D. (2021). Aktivitas AAntifungi dari Ekstrak (Mikania micrantha Kunth) Teirhadap Trichophyton meintagrophyteis dan Trichophyton rubrum. Jurnal Bioseinsei, 4(02), 9–19. https://doi.org/10.36526/bioseinsei.v4i02.1543

Putri, N. M., Putri, M. R., Elya, B., & Adawiyah, R. (2020). Aktivitas Antijamur Daun Polyscias scuteillaria Fosbeirg Meilawan Candida albicans. 7(3), 166–170.

Roslianizar, S., Lina, F., Tarigan, B., & Deiwi, N. P. (2022). Uji Aktivitas Antibakteiri Ekstrak Etanol Dan Etil Aseitat Daun Mangkokan (Polyscias scuteillaria (Burm.f.) Fosbeirg.) Teirhadap Peirtumbuhan Bakteiri Proteius vulgaris Dan Trichophyton meintagrophyteis. Jurnal Teikeisnos, 4(1).

Sabrina, A. P., Tania, E., Nurhalifah, N., Alvian, R., Veironita, S. C., Puji, S. I., & Nuryamah, S. (2022). STUDI FITOKIMIA DAN FARMAKOLOGI DAUN MANGKOKAN (Nothopanax scuteillarium). Jurnal Buana Farma, 2(2), 33–39. https://doi.org/10.36805/jbf.v2i2.384