UJI FRAKSI DAUN SEMBUNG (Blumea balsamifera (L.) Dc) TERHADAP  PENURUNAN KADAR GLUKOSA DARAH MENCIT (Mus musculus)

Yeni Agustin; Mayaranti Wilsya; Dila Natalia

doi:10.59003/nhj.v5i8.1880

Authors

Yeni Agustin Sekolah Tinggi Ilmu Kesehatan Siti Khadijah
Mayaranti Wilsya Sekolah Tinggi Ilmu Kesehatan Siti Khadijah
Dila Natalia Sekolah Tinggi Ilmu Kesehatan Siti Khadijah

DOI:

https://doi.org/10.59003/nhj.v5i8.1880

Keywords:

Sembung Leaf Fraction (Blumea balsamifera (L.) Dc), Sucrose, Blood Glucose Reduction, Mice (Mus musculus)

Abstract

Diabetes Mellitus is a metabolic disorder characterized by elevated blood glucose levels due to absolute or relative insulin deficiency. The Sembung plant (Blumea balsamifera (L.) Dc) is a medicinal plant traditionally used to help lower blood glucose levels. This study aimed to determine the effectiveness of sembung leaf fractions in reducing blood glucose levels in sucrose-induced mice. This research used a pre- and post-test control group design to compare blood glucose reduction between mice given a 4.2% concentration of Sembung leaf fractions and a positive control group treated with glibenclamide. The results showed that oral administration of Sembung leaf fractions at a 4.2% concentration reduced blood glucose levels at 120 minutes, with average results as follows: n-hexane fraction as 117.5 mg/dL, ethyl acetate fraction at 132.8 mg/dL, and water fraction at 113.5 mg/dL.The n-hexane fraction, ethyl acetate fraction, and water fraction of Sembung leaves were effective in reducing blood glucose levels in mice. Among them, the water fraction showed the greatest effect.

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