THE EFFECT OF ALOIN ON BLOOD SUGAR LEVELS IN STREPTOZOTOCIN-INDUCED WHITE MALE MICE (MUS MUSCULUS)
DOI:
https://doi.org/10.59003/nhj.v3i7.1083Keywords:
Aloin, Blood Sugar, STZAbstract
Blood, a lack of insulin secretion, insulin metabolism and both. One herb that works as well as drop in blood glucose levels and repair the metabolism of insulin is an aloin founded in aloe vera. Aims. Knowing the effect of aloin on white male mice (Mus musculus) induced by STZ. Methode. The type of research is experimental with the approach "pre-post test control group design". The population in the study is the white male (Mus musculus) 2-3 months, weighing 20-40 grams by 24 mice obtained from the university's pharmacological laboratory of Andalas. This sample was random with 24 mice. Data analysis shows the results of distribution are abnormal so the analysis tests used to friedman and the hoc wilcoxon post test. Results. The highest levels of blood glucose include K (+) 1, which is 273.5 mg/dL are affected by aloin for a drop in blood glucose in STZ (mus musculus), based on wilcoxon's test on K (+) 2 on metformin, P1 aloin dose 0.5 mg/kg, P2 dose 1 mg/kg has the same strength in drop in blood glucose level 0.028 and the most decline in pre-post value in P2 aloin group 1 mg/dL. Conclusion. There are effects of metformin administration, aloin dose 0.5 mg/kg and 1 mg/kg on lower blood glucose, aloin dose 0.5 mg/kg and aloin 1 mg/kg could be used as replacement therapy.
Downloads
References
Amriani, Y. A. and Tuahatu, J. W. (2021) ‘Uji Aktivitas Antidiabetes Ekstrak Etanol Akar Kabau (Archidendron bubalinum (Jack) I.C. Nielsen) terhadap Tikus Putih Jantan yang Diinduksi Diet Tinggi Lemak dan Fruktosa’, Jurnal Penelitian Sains, 23(2), pp. 102–109. doi: 10.56064/jps.v23i2.635.
Bintang Bella Pertiwi, M. et al. (2021) ‘Level Glukosa Darah pada Mencit Diabetes Setelah Pemberian Ekstrak Rumput Laut Coklat (Phaeophyta) (Blood Glucose Levels in Diabetic Mice After Giving Brown Seaweed (Phaeophyta) Extract)’, Level Glukosa Darah pada Mencit Diabetes Setelah Pemberian…. e-Journal Pustaka Kesehatan, 9(2), p. 84.
Busineni Jayasimha Goud, Dwarakanath.V, B. K. C. swamy (2015) ‘Streptozotocin - A Diabetogenic Agent in Animal Models’, Human Journals, 3(1), pp. 253–269. Available at: https://ijppr.humanjournals.com/wp-content/uploads/2015/04/18.Busineni-Jayasimha-Goud-Dwarakanath.V-B.K.Chikka-swamy.pdf.
Care, D. and Suppl, S. S. (2019) ‘Introduction : Standards of Medical Care in Diabetes d 2019’, 42(January), pp. 2018–2019.
D Abdullah, S Poddar, RP Rai, E Purwati, NP Dewi ‘Molecular identification of lactic acid bacteria an approach to sustainable food security’ - Journal of Public Health Research, 2021
Fajrunni’mah, R., Lestari, D. and Purwanti, A. (2017) ‘Faktor Pendukung dan Penghambat Penderita Diabetes Melitus dalam Melakukan Pemeriksaan Glukosa Darah’, Global Medical & Health Communication (GMHC), 5(3), p. 174. doi: 10.29313/gmhc.v5i3.2181.
Fatimah, R. N. (2015) ‘Diabetes Melitus tipe 2’, J Majority, 4, pp. 93–101.
Furman, B. L. (2021) ‘Streptozotocin-Induced Diabetic Models in Mice and Rats’, Current Protocols, 1(4), pp. 1–21. doi: 10.1002/cpz1.78.
Isdamayani, L. and Panunggal, B. (2015) ‘Kandungan Flavonoid, Total Fenol, Dan Antioksidan Snack Bar Sorgum Sebagai Alternatif Makanan Selingan Penderita Diabetes Mellitus Tipe 2’, Journal of Nutrition College, 4(4), pp. 342–349. doi: 10.14710/jnc.v4i4.10108.
Kementrian kesehatan republik indonesia (2020) Tetap Produktif, Cegah Dan Atasi Diabetes Mellitus, pusat data dan informasi kementrian kesehatan RI. Jakarta Selatan.
Kleinberger, J. W., Pollin, T. I. and Medicine, G. (2016) ‘Personalized Medicine in Diabetes Mellitus: Current Opportunities and Future Prospects’, 1346(1), pp. 45–56. doi: 10.1111/nyas.12757.Personalized.
Marhaeni, L. S. (2020) ‘Potensi Lidah Buaya (Aloe vera Linn) sebagai Obat dan Sumber Pangan’, Jurnal Ilmu-Ilmu Pertanian, 13(1), pp. 32–39.
NP Dewi, D Abdullah, AT Vani – ‘Identifikasi kuarsetin dengan teknik klt dan hplc pada Aloe vera barbadensis miller’ Jurnal Kesehatan Medika Saintika, 2020
Rahmasari, I. and Wahyuni, E. S. (2019) ‘Efektivitas Momordica carantia (pare) terhadap Penurunan Kadar Glukosa Darah’, Jurnal Ilmiah Rekam Medis dan Informatika Kesehatan, 9(1), pp. 57–64.
De Rosa, S. et al. (2018) ‘Type 2 diabetes Mellitus and Cardiovascular Disease: Genetic and Epigenetic Links’, Frontiers in Endocrinology, 9(JAN), pp. 1–13. doi: 10.3389/fendo.2018.00002.
Sari, R. P. (2021) Uji Aktivitas Antioksidan dan Antidiabetes Ekstrak Etanol dan Fraksi Daun Morbesi-besi (Tarenna polycarpa(miq) Koord. Ex Valenton) terhadap Mencit yang Diinduksi Streptozotocin, Jurnal Pembangunan Wilayah & Kota. Universitas Sumatera Utara.
Septiani, Fatimah-muis, S. and Anjani, G. (2020) ‘Aktivitas Antioksidan dan Kadar Aloin pada Lidah Buaya (ALOE VERA CHINENSIS)’, Jurnal Medika Indonesia, 1(2), pp. 17–24.
Zhong, R. et al. (2022) ‘Anti-Diabetic effect of aloin via JNK-IRS1/PI3K Pathways and Regulation of Gut Microbiota’, Food Science and Human Wellness, 11(1), pp. 189–198. doi: 10.1016/j.fshw.2021.07.019.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Rendri Bayu Hansah
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
NHJ is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Articles in this journal are Open Access articles published under the Creative Commons CC BY-NC-SA License This license permits use, distribution and reproduction in any medium for non-commercial purposes only, provided the original work and source is properly cited.
Any derivative of the original must be distributed under the same license as the original.
