MEKANISME PENSINYALAN VASCULAR ENDOTHELIAL GROWTH FACTOR DALAM PERKEMBANGAN DAN PENYEBARAN KANKER

Nana Liana; Roland  Helmizar; Ruhsyahadati Ruhsyahadati; Rahma Triyana; Muhammad Rizki Saputra

doi:10.59003/nhj.v5i3.1598

Authors

Nana Liana Universitas Baiturrahmah
Roland Helmizar Universitas Baiturrahmah
Ruhsyahadati Ruhsyahadati Universitas Baiturrahmah
Rahma Triyana Universitas Baiturrahmah
Muhammad Rizki Saputra Universitas Baiturrahmah

DOI:

https://doi.org/10.59003/nhj.v5i3.1598

Keywords:

Angiogenesis, Tumor invasion, VEGF

Abstract

Vascular Endothelial Growth Factor (VEGF) is a key mediator in the process of angiogenesis, playing a crucial role in the development and spread of malignant tumors. VEGF consists of several isoforms, primarily VEGF-A, which exert their effects through receptors VEGFR-1, VEGFR-2, and VEGFR-3, as well as co-receptors neuropilin-1 and -2. Activation of VEGF signaling pathways stimulates endothelial cell proliferation, migration, and survival, increases vascular permeability, and facilitates the formation and invasion of tumor-associated blood vessels. VEGF expression is regulated by various factors, including hypoxia via HIF-1α activation, oncogenes such as KRAS and Src, and the suppression of tumor suppressor genes such as p53 and PTEN. Additionally, several growth factors including EGF, PDGF, and IGF contribute to the regulation of VEGF. VEGF signaling also promotes tumor invasion by activating proteolytic enzymes such as MMP-2, MMP-9, and uPA, which degrade the basement membrane. Due to its central role in angiogenesis and tumor invasion, VEGF is a strategic target in anti-angiogenic therapies for various types of cancer. A comprehensive understanding of the structure, function, and regulation of VEGF is essential for the development of more effective molecular therapies.

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References

Kumar V, Abbas AK AJ. Robbins Basic Pathology. 10th ed. Philadelphia: Elsevier; 2018. 630–634 p.

Gunantara I. Ekspresi Vascular Endothelial Growth Factor Berhubungan Positif dengan Kedalaman Invasi pada Adenokarsinoma Kolorektal. Maj Patol. 2019;28(2):44–9.

Coleman WB, Tsongalis GJ. The Molecular Basis of Human Cancer. 2nd ed. New york: Springer; 2017. 757–770 p.

Hicklin DJ, Ellis LM. Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis. 2012;23(5):1011–27.

Karaman S, Leppa V matti. Vascular endothelial growth factor signaling in development and disease. 2018;1–8.

Elincovici CASTM, Ca ADBIBOŞ, Man SEŞUŞ, Rginean MAMĂ, Ihu CAM, Strate MII, et al. Vascular endothelial growth factor ( VEGF ) – key factor in normal and pathological angiogenesis. 2018;59(2):455–67.

Lamalice L, Boeuf FL HJ. Endothelial Cell Migration During Angiogenesis. 2007;782–94.

Pardali E GR dan WJ. Tumor Angiogenesis Regulators. Gonzalez-Perez RR, Rueda BR, editors. CRC Press. 2013;1–36.

Breier G. Mechanisms of Angiogenesis Edited. Breier MC and G, editor. Berlin; 2005.

M. Christiane Brahimi-Horn, Julie Laferrière, Nathalie Mazure and JP. Tumor Angiogenesis Basic Mechanisms and Cancer Therapy. Fusenig DM dan N, editor. New York: Springer; 2008.

Schmoll H joachim. Critical Role of Anti-Angiogenesis and VEGF Inhibition in Colorectal Cancer.

Olsson A karin, Dimberg A, Kreuger J, Claesson-welsh L. REVIEWS VEGF receptor signalling — in control of vascular function. 2006;7(May):359–71.

Parikh AA, Fan F, Liu WB, Ahmad SA, Stoeltzing O, Reinmuth N, et al. Neuropilin-1 in Human Colon Cancer Expression , Regulation , and Role in Induction of Angiogenesis. 2004;164(6):2139–51.

Cao Y, Guangqi E, Wang E, Pal K, Dutta SK, Bar-sagi D. VEGF Exerts an Angiogenesis-Independent Function in Cancer Cells to Promote Their Malignant Progression. 2012;72(16):3912–9.

Karla Esbona, MS, Zhanhai Li, PhD, and Lee Wilke M. Intraoperative Imprint Cytology and Frozen Section Pathology for Margin Assessment in Breast Conservation Surgery: A Systematic Review. 2014;13(12):871–82.

Hansel DE, Wilentz RE, Yeo CJ. Expression of Neuropilin-1 in High-grade Dysplasia , Invasive Cancer , and Metastases of the Human Gastrointestinal Tract. 2004;28(3):347–56.