THE PROFILE OF COLORECTAL ADENOCARCINOMA AT DR. M. DJAMIL GENERAL HOSPITAL PADANG, INDONESIA

Nana Liana; Roland  Helmizar; Ruhsyahadati Ruhsyahadati; Sri Nani Jelmila; Rahma Triyana; Lismawati Lismawati

doi:10.59003/nhj.v4i1.1132

Authors

Nana Liana Universitas Baiturrahmah
Roland Helmizar Universitas Baiturrahmah
Ruhsyahadati Ruhsyahadati Universitas Baiturrahmah
Sri Nani Jelmila Universitas Baiturrahmah
Rahma Triyana Universitas Baiturrahmah
Lismawati Lismawati Universitas Baiturrahmah

DOI:

https://doi.org/10.59003/nhj.v4i1.1132

Keywords:

colorectal adenocarcinoma, anatomical location, differentiation grade, profile

Abstract

Colorectal carcinoma is the third most common malignancy in the world. This malignancy originates from the epithelium of the colon and/or rectum, showing glandular or mucinous differentiation, where tumor cells have penetrated the muscularis mucosae layer. The study aims to report on epidemiological, clinical, and pathological characteristics of colorectal adenocarcinoma. Methods: We performed a retrospective descriptive study of 140 cases of colorectal adenocarcinoma in the gastroenterology and general surgery departments of M. Djamil General Hospital Padang, Indonesia conducted from January 2022 to December 2022. Data collection using medical records of patients in M. Djamil General Hospital Padang, Indonesia. We reported different data: Age, sex, site, and differentiation grade of the tumor. Results: Our study included 140 patients 80 males (57,1%) and 60 females (42.9%), with a median age range of 51-60 years. The tumors were found in the rectum 82 (58.6%), distal colon 37(26.4%), and proximal colon 21(15.0%). The differentiation grade was majority low grade 117 (83.6%). Conclusion: In conclusion, our result showed that colorectal adenocarcinoma is highest in the male population with an age range of 61-70 years. The most common site of adenocarcinoma is rectum. A low grade is the most differentiated grade.

Keywords: colorectal adenocarcinoma, anatomical location, differentiation grade, profile

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References

ID Nagtegaal, MJ Arends MST. Colorectal Carcinoma. In: Board WC of TE, editor. WHO Classification of Tumours digestive system tumors. 5th ed. IARC WHO; 2019. p. 177–87.

Bray F, Ferlay J SI. Global Cancer Statistics 2018 : Globocan Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. 2018;68:394–424.

WHO. IA for R on C. Cancer today [Internet]. [cited 2020 Apr 21]. Available from: https.://gco.iarc.fr/today/

Wong MCS, Ding H, Wang J, Chan PSF HJ. Prevalence and risk factors of colorectal cancer in Asia. 2019;17(3):317–29.

Chacko L, Macaron C, Burke CA. Colorectal Cancer Screening and Prevention in Women. 2015;

Downs-Kelly E, Rubin BP GJ. Epithelial Neoplasms of the Large Intestine. In: Odze RD GJ, editor. Odze and Goldblum Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas. 3rd ed. Philadelphia: Elsevier Saunders; 2015. p. 822–929.

Qi L DY. Screening of Differentiation-Specific Molecular Biomarkers for Colon Cancer. Cell Physiol Biochem. 2018;2543–50.

Ashwini K PR. A Study on Expression of Vascular Endothelial Growth Factor in Colorectal Malignancies and its Correlation with Various Clinicopathological Parameters. 2018;1–4.

Gunasekaran V, Ekawati NP SI. Karakteristik klinikopatologi karsinoma kolorektal di RSUP Sanglah, Bali, Indonesia tahun 2013-2017. 2019;10(3):552–6.

Khaled El-Shami, Kevin C. Oeffinger, Nicole L. Erb, Anne Willis, Jennifer Bretsch MLPC. American Cancer Society Colorectal Cancer Survivorship Care Guidelines. CA Cancer J Clin. 2015;65(6):427–55.

Kumar V, Abbas AK AJ. Robbins Basic Pathology. 10th ed. Philadelphia: Elsevier; 2018. 630–634 p.

Group TIHW. Colorectal cancer screening.(IARC Handbooks of Cancer Prevention ; Volume 17. Lyon: IARC WHO; 2019. 14–21 p.

Roshan MHK, Tambo A PN. The role of testosterone in colorectal carcinoma : pathomechanisms and open questions. . EPMA J. 2016;1–10.

Krasanakis T, Nikolouzakis TK, Sgantzos M, Sapsakos TM, Souglakos J, Spandidos DA et al. Role of anabolic agents in colorectal carcinogenesis : Myths and realities. 2019;2228–44.

Park SH, Song CW, Kim YB, Kim YS, Chun HR, Lee JH, et al. Clinicopathological Characteristics of Colon Cancer Diagnosed at Primary Health Care Institutions. Intest Res. 2014;12(2):131.

Kim MJ, Lee HS, Kim JH, Kim YJ, Kwon JH, Lee JO et al. Different metastatic pattern according to the KRAS mutational status and site-specific discordance of KRAS status in patients with colorectal cancer. BMC Cancer. 2012;12:347.

Anggunan. Hubungan Antara Usia dan Jenis Kelamin dengan Derajat Diferensiasi Adenokarsinoma Kolon Melalui Hasil Pemeriksaan Histopatologi Di RSUD Dr. H. Abdul Moeloek Provinsi Lampung. J Med Malahayati. 2015;1(4):161–8.

Jayadi T TP. Hubungan Ekspresi Protein NM23-H1, Densitas Limfovaskuler Peri-tumoral dan Invasi Limfovaskuler dengan Stadium dan Diferensiasi Histopatologi Adenokarsinoma Kolorektal. 2013;22(2).

Nana L. Hubungan Ekspresi Vascular Endothelial Growth Factor (VEGF) dengan Derajat Diferensiasi dan Invasi Limfovaskular pada Adenokarsinoma Kolorektal. 2021;25279106(1):368–75. Available from: http://scholar.unand.ac.id/77177/%0Ahttp://scholar.unand.ac.id/77177/4/file4.pdf

Downs-Kelly E, Rubin BP GJ. Epithelial Neoplasms of the Large Intestine. In: JRG RDO, editor. Odze and Goldblum Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas. Philadelphia: Elsevier saunder; 2015. p. 822–829.

Pai RK, Gonzalo DH SD. Epithelial Neoplasms of the Colon. In: AE N, editor. Fenoglio-Preiser’s Gastrointestinal Pathology. 4th ed. Philadelphia: Wolter Kluwer; 2017. p. 886–927.