SEPSIS
DOI:
https://doi.org/10.59003/nhj.v6i1.2159Keywords:
sepsis, septic shock, organ dysfunction, infection, sepsis management, patient safety.Abstract
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. It remains one of the leading causes of morbidity and mortality worldwide, particularly among patients admitted to intensive care units. Sepsis can progress to septic shock, characterized by persistent hypotension, impaired tissue perfusion, and multiple organ failure if not promptly recognized and treated. Early diagnosis requires comprehensive clinical assessment, laboratory evaluation, and the use of screening tools such as the Sequential Organ Failure Assessment (SOFA) and quick SOFA (qSOFA) scores. The management of sepsis includes early fluid resuscitation, timely administration of empiric antibiotics, source control of infection, hemodynamic support, and continuous monitoring of organ function. Numerous studies have demonstrated that early recognition and adherence to evidence-based clinical guidelines significantly reduce mortality rates and improve patient outcomes. Therefore, increasing healthcare professionals’ awareness, implementing effective sepsis protocols, and promoting a multidisciplinary approach are essential to enhancing the quality of care and patient safety in sepsis management.
Downloads
References
Fernando SM, Rochwerg B, Seely AJE. Clinical implications of the third international consensus definitions for sepsis and septic shock (Sepsis-3). Cmaj. 2018;190(36):E1058-E1059. doi:10.1503/cmaj.170149
Irvan I, Febyan F, Suparto S. Sepsis dan Tata Laksana Berdasar Guideline Terbaru. JAI (Jurnal Anestesiol Indones. 2018;10(1):62.
Najamuddin M, Nurdin H, Muchtar F. Penatalaksanaan Syok Sepsis dengan Penyulit Cedera Ginjal Akut pada Pasien Peritonitis Sekunder. J Anestesi Perioper. 2020;8(3):194–205.
Perhimpunan Dokter Spesialis Penyakit Dalam Indonesia. Buku Panduan Praktik Klinis Penyakit Dalam. Jakarta: PAPDI; 2020.
Surviving Sepsis Campaign. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. Intensive Care Medicine. 2021.
Tambajong RN, Lalenoh DC, Kumaat L. Profil penderita sepsis di ICU RSUP Prof. Dr. R. D. Kandou Manadoperiode Desember 2014 – November 2015. e-CliniC. 2016;4(1). doi:10.35790/ecl.4.1.2016.11011
Tasya Ardiani, Mangarengi Y, Mulyadi FE, Sommeng F, Kusuma SI. Literature Review Uji Sensitivitas Antibiotik Terhadap Bakteri Penyebab Penyakit Sepsis. Fakumi Med J J Mhs Kedokt. 2022;2(4):251–9.
Wiriansya EP, Amalia DG, Tanra SH, et al. Manajemen Terapi Cairan pada Sepsis.Fakumi Med J. 2022;2(6):393-407.
WHO. Global Report on the Epidemiology and Burden of Sepsis: Current Evidence, Identifying Gaps and Future Directions.; 2020. http://apps.who.int/bookorders.%0Ahttp://apps.who.int/bookorders.%0Ahttps://apps. who.int/iris/bitstream/handle/10665/334216/9789240010789-eng.pdf
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Yulson
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
NHJ is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Articles in this journal are Open Access articles published under the Creative Commons CC BY-NC-SA License This license permits use, distribution and reproduction in any medium for non-commercial purposes only, provided the original work and source is properly cited.
Any derivative of the original must be distributed under the same license as the original.
