UJI EFEKTIVITAS EKSTRAK ZINGIBER PURPUREUM TERHADAP PENURUNAN BERAT BADAN PADA TIKUS JANTAN MODEL OBESITAS

Riki Nova; Dessy Abdullah; Annisa Astari

doi:10.59003/nhj.v4i7.1335

Authors

Riki Nova Universitas Baiturrahmah
Dessy Abdullah Universitas Baiturrahmah
Annisa Astari Universitas Baiturrahmah

DOI:

https://doi.org/10.59003/nhj.v4i7.1335

Keywords:

Bangle, herbal, obesity, weight loss, Wistar rats, Zingiber purpureum

Abstract

Background: Obesity is a global health issue that continues to rise, requiring safe and effective solutions. Although chemical weight loss medications are widely available, their use often leads to harmful side effects. This has encouraged people to turn to safer and more affordable herbal treatments. Objective: This study aims to determine the effectiveness of Zingiber purpureum extract in reducing body weight in male obesity rat models. Methods: This study employed a true experimental design with a pretest-posttest control group. A total of 20 male Wistar rats were divided into five groups: negative control (rats with standard feed without treatment), positive control (rats with high-fat diet without treatment), comparator (orlistat at a dose of 10.8 mg/kgBW), treatment 1 (Zingiber purpureum extract at a dose of 100 mg/kgBW), and treatment 2 (Zingiber purpureum extract at a dose of 200 mg/kgBW). The rats were induced with obesity using a high-fat diet for 6 weeks, followed by treatment for 28 days. Body weight measurements were taken weekly on days 7, 14, 21, and 28 after treatment. Data analysis was presented in the form of descriptive distribution, and One-Way ANOVA was performed. Results: The results of the study showed a reduction in body weight in the treatment groups 1 and 2 with Zingiber purpureum extract, with a significant statistical difference on days 21 and 28 in the treatment 2 group (200 mg/kgBW) compared to the positive control group (p<0.05). Zingiber purpureum extract has potential in reducing body weight through a mechanism that is suspected to involve the inhibition of lipase enzyme activity. Conclusion: There was a reduction in body weight following the administration of Zingiber purpureum extract in male obesity rat models. This suggests that Zingiber purpureum extract has the potential to be a natural and safer herbal alternative for obesity management.

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