ATOPIC MARCH
DOI:
https://doi.org/10.59003/nhj.v6i1.2145Keywords:
atopic march, atopic dermatitis, allergic rhinitis, asthma, allergic disease progression.Abstract
Atopic March refers to the natural progression of allergic diseases that commonly begins in early childhood and develops sequentially into other atopic conditions later in life. The condition typically starts with atopic dermatitis in infancy, followed by food allergies, allergic rhinitis, and asthma during childhood. The pathogenesis of atopic march involves a complex interaction between genetic predisposition, immune dysregulation, environmental exposure, and skin barrier dysfunction. Impaired skin integrity facilitates allergen sensitization, leading to chronic inflammatory responses mediated predominantly by immunoglobulin E (IgE). Clinical manifestations vary depending on the stage of disease progression and may significantly affect the quality of life of affected individuals. Diagnosis is based on clinical history, physical examination, and allergy testing when indicated. Management focuses on early identification, avoidance of triggering allergens, skin barrier protection, pharmacological therapy, and patient education to prevent disease progression and reduce complications. Early intervention is essential to improve long-term outcomes and minimize the burden of allergic diseases.
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References
Salazar-espinosa JF. The Atopic March . A Literature Review. 2014;2(3):119–24.
Zheng T, Yu J, Oh MH, Zhu Z. The Atopic March : Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma. 2011;3(2):67–73.
Tsuge M, Ikeda M, Matsumoto N, Yorifuji T, Tsukahara H. Current Insights into Atopic March. 2021;1–17.
Atopic March or Atopic Multimorbidity — Overview of. 2024;
Zeiger RS, Schatz M, Zhou B, et al. Impact of Food Allergy on the Atopic March Progression From Atopic Dermatitis in Early Childhood to Other Atopic Disorders at School Age. J Allergy Clin Immunol Pract 2025;13(8):1991–2003.
Zhao S, Hwang A, Miller C, Lio P. Safety of topical medications in the management of paediatricatopic dermatitis: An updated systematic review. Br J Clin Pharmacol 2023;89(7):1911–2333.
Dribin TE, et al. Trends and variation in pediatric anaphylaxis care. Journal of Allergy and Clinical Immunology: In Practice. 2023.
Pistiner M, et al. Factors associated with epinephrine use in infants and toddlers. Journal of Allergy and Clinical Immunology: In Practice. 2024.
Perlman L, et al. Management of food-induced anaphylaxis in children. Annals of Allergy, Asthma & Immunology. 2024.
Food Allergies: Diagnosis, Treatment, and Prevention. American Family Physician. 2023
Alissa C, Alexander W, Arntz JL, et al. Prenatal antibiotic exposure, asthma, and the atopic march: A systematic review and meta-analysis. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons 2022;7(11):3233–3248.
Goh MS, Yun JS, Su JC. Management of atopic dermatitis: a narrative review. Medical Journal of Australia 2022;216(11):587–593.
Tham EH, Leung DYM. Mechanisms by Which Atopic Dermatitis Predisposes to Food Allergy and the Atopic March. Allergy Asthma Immunol Research 2019;11(1):4–15.
Karavaizoglu C, Dolu KO, Suleyman A, Yucel E, Altintas E, Demirkale ZH. Phenotypes and natural course of atopic dermatitis: A pathway to the atopic march. Int Arch Allergy Immunol 2025;1–15.
Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM. Nelson Textbook of Pediatrics, 21st Edition. Philadelphia: Elsevier; 2020. (Definisi dan epidemiologi dasar)
Adkinson NF, Bochner BS, Burks AW, Busse WW, Holgate ST, Lemanske RF, O’Hehir RE.
Middleton’s Allergy: Principles and Practice, 9th Edition. Philadelphia: Elsevier; 2020. (Definisi dan mekanisme imunologi)
MIMS Indonesia. Dermatitis Atopik: Disease Background. 2026. (Data epidemiologi global dan Indonesia)
Spergel JM. “The atopic march: link to upper airways.” Annals of Allergy, Asthma & Immunology. 2010;104(4):273–277.
Jurnal Medical Profession (Medpro). Prevalensi Dermatitis Atopik. Vol. 6 No. 2, Juni 2024. (Data epidemiologi Indonesia, Asia, dan dunia)
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