GAMBARAN EFEK SAMPING PENAMBAHAN MORFIN INTRATEKAL PADA PASIEN SECTIO CAESAREA DENGAN ANESTESI SPINAL DI RUMAH SAKIT HERMINA PADANG TAHUN 2026
DOI:
https://doi.org/10.59003/nhj.v6i1.2138Keywords:
Side Effects, Intrathecal Morphine, Spinal Anesthesia, Cesarean SectionAbstract
Cesarean section (CS) is an obstetric surgical procedure that has seen a significant global increase. Post-CS patients commonly experience moderate-to-severe acute pain at the abdominal wall and uterine incision sites. A multimodal analgesia strategy effectively utilized to provide long-lasting pain relief is the administration of intrathecal morphine as an adjuvant to spinal anesthesia. Although proven effective in extending the pain-free interval, the use of intrathecal morphine carries risks of specific side effects that necessitate routine monitoring. To determine the side effect profile of intrathecal morphine adjuvant among patients undergoing Cesarean section (CS) under spinal anesthesia at Hermina Hospital Padang in 2026. This was a quantitative descriptive study utilizing a cross-sectional design. The sample comprised patients undergoing CS under spinal anesthesia with intrathecal morphine adjuvant at Hermina Hospital Padang in 2026 who met the inclusion and exclusion criteria. Data collection instruments included observation sheets and medical records to evaluate demographic characteristics and the incidence of postoperative side effects. The minimum required sample size was 30 samples. Regarding patient characteristics, the majority fell within the healthy reproductive age range of 20–35 years, accounting for 28 individuals (84.84%), most were primiparous (54.53%), and a majority of 19 patients (57.57%) had no prior history of CS. The most predominant side effect observed among respondents was nausea and vomiting, occurring in 8 cases (24.24%), followed by pruritus in 7 cases (21.21%). Additionally, a concurrent combination of nausea-vomiting and pruritus was observed in 4 cases (12.12%). Severe side effects, such as somnolence, urinary retention, and respiratory depression, were entirely absent among all respondents in this study. Conclusion: The administration of intrathecal morphine as an adjuvant to spinal anesthesia in CS patients at Hermina Hospital Padang in 2026 was shown to be relatively safe. The most frequently occurring side effects were mild-to-moderate, namely nausea-vomiting and pruritus, with no severe adverse effects reported.
Downloads
References
Napisah P, Dharma S BH. Intervensi Untuk Menurunkan Nyeri Post Sectio Caesarea. J Inov Ris Ilmu Kesehat [Internet]. 2022;2:1. Available from: https://doi.org/10.51878/healthy.v1i2.1113
Yusuf GN, Devita H, Andriyan EF, Pasalina PE. Pengaruh Mobilisisasi Dini Terhadap Penurunan Rasa Nyeri pada Pasien Post Sectio Caesarea dengan Spinal Anestesi di RSUD Padang Panjang. J Kesehat. 2024;13(1):8–15.
Sutisna EH, Sukmawati A, Mulyani I. Pengaruh Relaksasi Genggam Jari Terhadap Pasien Pasca Operasi Untuk Penurunan Nyeri Sectio Caesarea. J Asuhan Ibu dan Anak. 2023;8(2):89–95.
Salman Hidayat. Pengaruh Relaksasi Terhadap Penurunan Intensitas Nyeri Pada Pasien Post Operasi Hemoroid Di Rumah Sakit Tk. Ii Dr. Ak. Gani Palembang Tahun 2019. J Kesehat. 2019;27(2):635–7.
Pinzon RT. Manajemen Nyeri. Buku pengkajian nyeri. 2016. 54+vi.
Nurani IA, Huda MH, Argarini D. Analisis Efektifitas Penerapan Enhanced Recovery After Cesarean Section (Eracs) Terhadap Nyeri Dan Mobilisasi Dini Pada Pasien Post-Sc Di Rs Hermina Jatinegara. J Keperawatan dan Kebidanan Nas. 2024;1(2):23–30.
Kintu A, Abdulla S, Lubikire A, Nabukenya MT, Igaga E, Bulamba F, et al. Postoperative pain after cesarean section: Assessment and management in a tertiary hospital in a low-income country. BMC Health Serv Res. 2019;19(1):1–6.
Putra Radetyo S, Tri Yudono D, Yanti L, Harapan Bangsa U, Studi Keperawatan Anestesiologi Program Sarjana Terapan P. Gambaran Tingkat Nyeri Pada Pasien Pasca Operasi Sectio Caesarea Dengan Teknik Anestesi Spinal di Bangsal Rumah Sakit Umum Daerah dr. R. Goeteng Taroenadibrata Purbalingga. J Ilm Multidisiplin [Internet]. 2024;2(9):89–93. Available from: https://doi.org/10.5281/zenodo.13729967
Moisa RC, Negrut N, Botea MO, Bodog TM, Moisa CCM, Thomas TC, et al. Optimizing Intrathecal Opioid Strategies for Cesarean Section: A Comprehensive Narrative Review of Pharmacology, Clinical Outcomes, and Safety. Cureus. 2025;17(4).
Putri GW, Yasmin S, Julinar. Distribusi usia dan primipara pada ibu bersalin. 2024;
Dewi Y, dkk. Pengaruh Mobilisasi Dini terhadap Penurunan Intensitas Nyeri pada Ibu Post Sectio Caesarea di RS TK III Dr. Reksodiwiryo Padang. Meditory J Ilmu Kesehat. 2023;11(1):34–40.
Norbaiti, Nuriaty RS, Ariady D, Anisa N. Hubungan Paritas Dan Usia Ibu Dengan Kejadian Sectio Caesarea Di RSUD Ulin Banjarmasin Tahun 2023. Nurs Appl J. 2023;
PA O, Rahayu S, NKE A. Faktor-Faktor yang Berhubungan dengan Persalinan Sectio Caesarea di Rumah Sakit Umum Bali Royal Tahun 2023. Midwifery Care J [Internet]. 2024;5(4). Available from: https://ejournal.poltekkes-smg.ac.id/ojs/index.php/micajo/article/view/11890
Bollag L. Management of opioid side effects in obstetric anesthesia. Anesthesiol Clin. 2021;
Oktarini PA, Rahayu S, Astiti NKE. Faktor-Faktor Yang Berhubungan Dengan Persalinan Sectio Caesarea Di Rumah Sakit Umum Bali Royal Tahun 2023. Midwifery Care J. 2023;
Anggraini F. Analysis of Factors Related to Pregnancy Indications, Parity, and Psychology of Normal Labor Pain to the Incidence of Sectio Caesarean (SC) Labor at Jakarta Port Hospital. ABDIMAS J Pengabdi Masy. 2024;
Hayati N, Pujiati P, NT S. Hubungan Antara Cephalopelvic Disproportion (CPD), Gawat Janin dan Partus Lama dengan Kejadian Sectio Caesarea (SC) pada Ibu Primipara di RSIABDT Tahun 2022. SENTRI J Ris Ilm [Internet]. 2022;2(5). Available from: https://ejournal.nusantaraglobal.ac.id/index.php/sentri/article/view/822
Retni A, Harismayanti, Malapo A. Karakteristik ibu bersalin dengan sectio caesarea. J Kesehat Tambusai. 2023;
AAF F, RD J. Indications for Sectio Caesarea Delivery: Literature Review. Int J Res Publ. 2023;139(1):65–72.
Ananda D, Sari EP, Sari I, Anggraini A. Faktor-faktor yang berhubungan dengan tindakan Sectio Caesarea pada ibu bersalin di RSUD Kayu Agung tahun 2023. Indones J Heal Sci. 2025;5(1):1–10.
Gehling M, Tryba M. Risks and side-effects of intrathecal morphine combined with spinal anaesthesia: a meta-analysis. Br J Anaesth. 2024;
Liu X. Intrathecal injection of morphine induces pruritus via central signaling pathways. Neuroscience. 2024;
Varma D. Does intrathecal morphine increase postoperative complications? Medscape. 2024;
Wendling AL, Cates JN, Garvan C, Lopez B, Cometa MA, Andoniadis M. Intramuscular promethazine added to IV ondansetron for the prevention of intrathecal morphine-induced pruritus and nausea after cesarean delivery: a randomized controlled trial. Cureus. 2025;
Wu CL. Opioid-related side effects in obstetric anesthesia. J Clin Anesth. 2022;
Nguyen E, Lim G, Ross SE. Mechanistic insights into spinal neurones involved in neuraxial opioid-induced pruritus. Br J Anaesth. 2021;
Cadd M, Jackson P, Ewnetu B. Ondansetron for the prevention of pruritus in women undergoing cesarean delivery with intrathecal opioid: a systematic review and meta-analysis. Anesth Analg. 2024;
Uchimura S, Yano T, Tsuneyoshi I. Effect of intravenous hydroxyzine on intrathecal morphine-induced pruritus after cesarean section. Minerva Anestesiol. 2024;
Qin J, Wang X, Wang X, Liu F, Feng C. Intrathecal injection of morphine induces pruritus via the NMDAR-Akt signaling pathway. ACS Chem Neurosci. 2025;
Carvalho B. Intrathecal morphine for postoperative analgesia: current trends. Anesth Analg. 2020;
Lee LA. Neuraxial opioid safety and outcomes. Anesthesiology. 2023;
Sultan P. The effect of intrathecal opioids in cesarean delivery. Anaesthesia. 2021;
Sultan P, Halpern S, Pushpanathan E. The effect of intrathecal opioids in cesarean delivery: a systematic review and meta-analysis. Anaesthesia. 2021;76(6):851–61.
Sharawi N. Neuraxial morphine and respiratory depression. Reg Anesth Pain Med. 2020;
Husaini SW. Safety of intrathecal morphine in cesarean section. J Anesth Clin Res. 2023;
Arzola C, Wieczorek PM. Efficacy of low-dose intrathecal morphine. Int J Obstet Anesth. 2020;
Anesthesiologists AS of. Practice Guidelines for Obstetric Anesthesia. 2022.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Perdana Rizky

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
NHJ is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Articles in this journal are Open Access articles published under the Creative Commons CC BY-NC-SA License This license permits use, distribution and reproduction in any medium for non-commercial purposes only, provided the original work and source is properly cited.
Any derivative of the original must be distributed under the same license as the original.



















