RASIO NEUTROFIL LIMFOSIT PADA PASIEN DEMAM TIFOID DI RUMAH SAKIT ISLAM SITI RAHMAH PADANG TAHUN 2023

Debie  Anggraini; Nirmala Nirmala; Rahma Triyana

doi:10.59003/nhj.v4i12.1433

Authors

Debie Anggraini Universitas Baiturrahmah
Nirmala Nirmala Universitas Baiturrahmah
Rahma Triyana Universitas Baiturrahmah

DOI:

https://doi.org/10.59003/nhj.v4i12.1433

Keywords:

Typhoid Fever, Neutrophil, Lymphocyte, Neutrophil Lymphocyte Ratio

Abstract

Typhoid fever is an acute infection caused by Salmonella typhi, primarily occuring in developing countries, this condition can be diagnosed in various ways, one of which is through the neutrphil-lymphocyte-rasio (NLR) as an indikator of body inflammation. This study aims to assess the NLR typhoid fever patients at Siti Rahmah Islamic Hospital, Padang in 2023, as well asthe distribution based on age, gender, body temperature, and patient outcomes. This study employed a descriptive observational method with a cross-sectional design. Data were obtained from the medical records of typhoid fever patients who underwent at the hospital 2023. The sample was taken using a total sampling method, involving 29 patients. The study involved 29 typhoid fever patients, the majority of whom were female (65,5%) andn most commonly aged 0-5 years (44,8%). Most patients exhibited neutophilia (>70%) at 89,7% and lymphocytopenia (<20%) at 86,2%. The mean NLR value was 6,32, indicating inflammation. Most patients had febrile body temperature (38-39,9°C) at 65,5%. Based on the tubex scale 55,2% of patients had values greater than 6, indicating a strong likelihood of typhoid infection. A total of 65,5% of patients showed improvement after treatment. The NLR indicates an increas in neutrophil rasio and decrease un lymphocytes in typhoid fever patients. This study emphasizes the importance of NLR examination as supporting diagnositic tool and clinical management of typhoid fever.

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References

Levani Y, Prastya AD. Demam Tifoid: Manifestasi Klinis, Pilihan Terapi Dan Pandangan Dalam Islam. Al-Iqra Med J J Berk Ilm Kedokt. 2020;1(2):10–6.

Idrus HH, Utami N, Rahmawati R, Daeng Kanang IL, Musa IM, Rasfayanah R. Analisis Penggunaan Antibiotik Pasien Demam Tifoid dengan Komplikasi dan Tanpa Komplikasi yang Dirawat di Rumah Sakit. UMI Med J. 2023;8(1):46–52.

Mustamin AT, Gobel FA, Sololipun AM. Faktor Determinan Demam Typhoid Di Puskesmas Bontoramba Kabupaten Jeneponto. Wind Public Heal J. 2022;3(2):775–87.

Sumarni D. Hubungan Pengetahuan Dan Sikap Ibu Terhadap Perawat Demam Thypoid Pada Anak Di RSUD Pariaman. Initium Medica J. 2021;1(1):2.

Manalu TN, Rantung J. Faktor-Faktor yang Mempengaruhi Kejadian Demam Tifoid. J Penelit Perawat Prof. 2021;3(November):653–60.

Raharti I, Yuniarti E, Handayani EW. Gambaran Peresepan Antibiotik, Biaya, Efektifitas Terapi Pasien Demam Tifoid Rawat Inap RS Palang Biru Kutoarjo. J Sains dan Kesehat. 2022;4(2):176–80.

Sucipta M. Baku Emas Pemeriksaan Laboratorium Demam Tifoid pada Anak. J Skala Husada [Internet]. 2015;12(1):22–6. Available from: http://poltekkes-denpasar.ac.id/files/JSH/V12N1/A.A Made Sucipta.pdf

Nurhidayah MR, Arfijanto MV, Dwi A, Widodo W, Kholili U. Profil Rasio Neutrofil Terhadap Limfosit Pada Pasien Dengan Dugaan Demam Tifoid Di RSUD Dr. Soetomo Surabaya. Care J Ilm Ilmu Kesehat [Internet]. 2021;9(1):38–49. Available from: https://jurnal.unitri.ac.id/index.php/care/article/view/2042

Djohan H, Nuswantoro A, Harno. Hubungan Kadar C-Reactive Protein Dengan Neutrophil Lymphocyte Ratio ( NLR ) Pada Penderita Demam Tifoid. Pros Asos Institusi Pendidik Tinggi Teknol Lab Med Indones. 2023;2:212–25.

Nurmansyah, Dian. Putri, Silfanida. Wahyuni RAN. Profil Neutrophil-To-Lymphocyte Ratio Pada Demam Tifoid. 2023;(December):129–35.

Fachrizal Y, Handayani Y, Ashan H. Faktor-Faktor yang Berhubungan Dengan Kejadian Demam Tifoid pada Anak di Rumah Sakit Stroke Nasional Bukittinggi Tahun 2019. Sci J. 2022;1(3):237–46.

Shao H, Chen H, Xu K, Gan Q, Chen M, Zhao Y, et al. Investigating the Associations Between COVID-19, Long COVID, and Sleep Disturbances: Findings from a Cross-Sectional Study (Preprint). JMIR Public Heal Surveill. 2023;10:1–13.

Ramaningrum G, Anggraheny HD, Putri TP. Faktor-Faktor yang Mempengaruhi Kejadian Demam Tifoid Pada Anak di RSUD Tugurejo Semarang. Fak Kedokt Univ Muhammadiyah Semarang. 2017;10(2):1–8.

Nuruzzaman H, Syahrul F. Analisis Risiko Kejadian Demam Tifoid Berdasarkan Kebersihan Diri dan Kebiasaan Jajan di Rumah. J Berk Epidemiol. 2016;4(1):74–86.

Rakhman A, Humardewayanti R, Pramono D, Kesehatan Kabupaten Bulungan D, Timur K, Internal B, et al. Faktor-Faktor Risiko Yang Berpengaruh Terhadap Kejadian Demam Tifoid Pada Orang Dewasa Risk Factors Affecting the Incidence of Typhoid Fever in Adults. Ber Kedokt Masy. 2009;25(4):167.

. Z., Hadi S, Amaliyah B. IK. Karakteristik Penderita Demam Tifoid di RS. Ibnu Sina Kota Makassar Tahun 2016 - 2017. UMI Med J. 2020;5(1):57–68.

Giacobbe DR. Techniques in Infectious Diseases Assessment of Hematological Parameters in Typhoid Fever. 2022;1–5.

Fitri Jamil K. The Comparison of The Clinical Symptoms of Thypoid Fever in Adult Patients (Tubex vs Widal) in Banda Aceh, Aceh Province, Indonesia. 2017;04:34–42.

Shrivastava K, Vahikar S, Mishra V. Hematological profile in typhoid fever. Trop J Pathol Microbiol. 2015;1(1):16–20.

Buonacera A, Stancanelli B, Colaci M, Malatino L. Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases. Int J Mol Sci. 2022;23(7).

Anabire NG, Aryee PA, Helegbe GK. Hematological abnormalities in patients with malaria and typhoid in Tamale Metropolis of Ghana. BMC Res Notes [Internet]. 2018;11(1):1–6. Available from: https://doi.org/10.1186/s13104-018-3456-9

Nazilah AAS. Hubungan Derajat Kepositifan TUBEX TF dengan Angka Leukosit pada Pasien Demam Tifoid Patients with Typhoid Fever. Mutiara Med. 2015;13(3):173–80.

Lestari RP, Arguni E. Profil Klinis Anak dengan Demam Tifoid di Rumah Sakit Umum Pusat Dr Sardjito Yogyakarta. Sari Pediatr. 2018;19(3):139.

Ansyar SI. KARAKTERISTIK PENDERITA DEMAM TIFOID YANG DIRAWAT INAP DI RSUP DR. TADJUDDIN CHALID MAKASSAR TAHUN 2022. Nucl Phys. 2023;13(1):104–16.

Afifah NR, Pawenang ET. Kejadian Demam Tifoid pada Usia 15-44 Tahun Nur. Higea J Public Heal Res Dev. 2019;3(2):263–73.