THE CORRELATION BETWEEN NEURON-SPECIFIC ENOLASE (NSE) SERUM LEVEL AND TRAUMATIC BRAIN INJURY SEVERITY

Dian Ayu Hamama Pitra; Yuliarni Syafrita; Rika Susanti; Rauza Sukma Rita

doi:10.59003/nhj.v5i1.1498

Authors

Dian Ayu Hamama Pitra Doctoral Study Programme in Biomedical Science, Faculty of Medicine, Universitas Andalas, Indonesia and Department of Neurology, Faculty of Medicine, Universitas Baiturrahmah, Indonesia
Yuliarni Syafrita Department of Neurology, Faculty of Medicine, Universitas Andalas, Indonesia
Rika Susanti Department of Forensic Medicine, Faculty of Medicine, Universitas Andalas, Indonesia
Rauza Sukma Rita Department of Biochemistry, Faculty of Medicine, Universitas Andalas, Indonesia

DOI:

https://doi.org/10.59003/nhj.v5i1.1498

Keywords:

Traumatic brain injury, Neuron-Specific Enolase, NSE, Glasgow Coma Scale

Abstract

Traumatic brain injuries (TBIs) are a health and socio-economic problem worldwide, both in low- and high-income countries, that affects all age groups. Computed Tomography (CT) is a diagnostic modality that can be used to assess brain damage. However, there are some limitations in the use of CT in TBIs. Therefore, biomarkers are expected to be a solution to identify brain injuries. Neuron-Specific Enolase (NSE) is a more practical and cheaper alternative. It does not require patient mobilization, especially for patients with severe TBIs, to accompany clinical examinations and CT. Methods: A cross-sectional design was used to determine the correlation between Neuron Specific Enolase (NSE) serum levels and the severity of TBIs at RSUP Dr. M. Djamil, Padang. Results: The study found that most patients were 23 men (76.7%), consisting of adults (40.0%). The majority of patients had mild traumatic brain injury (GCS 13-15) in 18 people (60.0%). The cut-off point for serum NSE was 6.6 ng/ml using the ROC curve. There was a negative correlation between serum NSE levels and the severity of TBI (r=-0.211). Conclusion: The correlation of serum NSE levels with the severity of TBI was very weak.

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