UJI EFEKTIFITAS EKSTRAK SAFFRON (CROCCUS SATIVUS) SEBAGAI ALTERNATIF DIAZEPAM TERHADAP HEART RATE PADA TIKUS CIRCADIAN RHYTME SLEEP DISORDER (CRSD)

Suharni Suharni; Raditya Pangestu; Tania Putri Zulkifli; M. Ferdi Devilito; Ardi Khusnaidi; Afdila Syarfina

doi:10.59003/nhj.v4i7.1340

Authors

Suharni Suharni Universitas Baiturrahmah
Raditya Pangestu Universitas Baiturrahmah
Tania Putri Zulkifli Universitas Baiturrahmah
M. Ferdi Devilito Universitas Baiturrahmah
Ardi Khusnaidi Universitas Baiturrahmah
Afdila Syarfina Universitas Baiturrahmah

DOI:

https://doi.org/10.59003/nhj.v4i7.1340

Keywords:

Circadian rhytme sleep disorder, Saffron, Diazepam, Heart Rate

Abstract

Circadian rhythm sleep disorder (CRSD) is a problem that affects people from waking to sleep. There are many ways to reduce the intensity of CRSD; one of them is by taking diazepam. However, the side effects of Diazepam are much more dangerous. Therefore, it is important to use herbal medicines as traditional medicines to maintain health so that they are safe for consumption, one of which is using turmeric (Crocus sativus). This research was conducted at the Pharmacy Laboratory, Universitas Perintis Indonesia. The goal of this study was to compare the average heart rate of rats treated with saffron and diazepam for sleep disorders. Turmeric extract and diazepam were given orally at a dose of 50 mg/KgBB and diazepam at a dose of 0.75 mg/KgBB, and 15 rats were used. Measurement of rats heart rate was carried out on the 1st, 7th, and 14th days. The results of the study concluded that the treatment of experimental animals by presenting saffron and diazepam extracts was able to reduce the average heart rate value in each rats, with data analysis showing that there was a significant difference in the heart rate of each with a value of P = 0.015 (P < 0.05). So it can be said that the use of saffron extract is effective in overcoming CRSD.

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References

Nur Sazaro Thudhur, 2019. Crocus sativus dan Insomnia 10, 193–196.

Priyatni, W.N., 2016. Berapa Kebutuhan Diazepam Untuk Memenuhi Pelayanan Kesehatan Di Indonesia ? Studi Kasus Konsumsi Diazepam Di Indonesia How Much of Diazepam Is Necessary in Order To Fulfill the Health Service in Indonesia ? J. Manaj. dan Pelayanan Farm. 6, 297–302.

Hosseinzadeh, H., Noraei, N.B., 2017. Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice. Phyther. Res. 23, 768–774.

Liu, Z., Xu, X.-H., Liu, T.-Y., Hong, Z.-Y., Urade, Y., Huang, Z.-L., Qu, W.-M., 2017. Safranal Enhances Non-Rapid Eye Movement Sleep in Pentobarbital-Treated Mice. CNS Neurosci. Ther. 18, 623–630.

Afifah, M.N., Hasanah, A.N., 2020. Saffron (Crocus sativus L): Kandungan dan Aktivitas Farmakologinya. Maj. Farmasetika 5, 116–123.

Dehghanmehr et al., S., Shadadi, H., Mansouri, A., Arbabisarjou, A., 2017. Effect of oral saffron capsules on sleep quality in patients with diabetes at Zabol-Iran. Bali Med. J. 6, 595.

Robert L Sack, M., Dennis Auckley, M., R. Robert Auger, M., Mary A, Carskadon, P., Kenneth P. Wright Jr, P., Micheal V. Vitiello, P., Iriana V. Zhdanove, M., 2017. Gangguan Tidur Ritme Sirkadian : Bagian I , Prinsip Dasar , Kerja Shift dan Gangguan Jet Lag 30, 1460–1483.

Zhu, L., Zee, P.C., 2018. Circadian Rhythm Sleep Disorders. Neurol Clin 30, 1167–1191